Anticholinergic Activity and Alzheimer's Disease
نویسندگان
چکیده
منابع مشابه
Anticholinergic Activity and Alzheimer's Disease.
AA cascade in AD’ or ‘progression of AD by its own mechanism’. Although there are AA-inducing factors other than downregulation of ACh (e.g. drugs, febrile illness or mental stress), upregulation of ACh is possible if the ACh system is not depressed or overloaded. Thus, upregulation of the ACh system can inhibit AA even in the presence of other factors ( fig. 1 ). The appearance of AA would the...
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We reported a procedure of serum anticholinergic activity (SAA) measurement and the reliability and reproducibility of the receptor binding assay, and we also described the usefulness of SAA measurement reflecting the anticholinergic activity (AA) in the central nervous system (CNS). According to the results of a 10 times repeated measurement of standard atropine binding, the relative error was...
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In this article, we review the downregulation of acetylcholinergic activity in schizophrenia and discuss the similarity and difference between Alzheimer's disease (AD) and schizophrenia in terms of acetylcholine (ACh) and anticholinergic activity (AA); then, we propose the use of cognition-enhancing therapy for schizophrenia. As ACh regulates an inflammatory system, when the cholinergic system ...
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The cholinergic deficit in Alzheimer’s disease (AD) remains the cornerstone for the understanding of chemical signal transfer. Hypofunctions of cholinergic systems are significantly involved in the signs and symptoms of senile dementia of the Alzheimer type. Cognitive deficits in AD have been widely associated with dysfunction of the cholinergic system. As a diagnostic marker of AD the activity...
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ژورنال
عنوان ژورنال: Neurodegenerative Diseases
سال: 2015
ISSN: 1660-2854,1660-2862
DOI: 10.1159/000381482